The crash happened shortly before 10 p.m. on Sunday on the AA Highway near Rocky View Rd.
The van hit the driver's side of the car.
The driver of the car died at the scene.
Two passengers in the car were taken to UC Medical Center, one with life-threatening injuries and the other with serious injuries.
The driver of the van was taken to St. Elizabeth Hospital in Fort Thomas with non-life-threatening injuries.
Police have not identified the victim of the crash. If anyone has information about the crash, they are asked to call the Cold Spring Police Department at 859-441-6289